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KMID : 0043320210440040427
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Archives of Pharmacal Research
2021 Volume.44 No. 4 p.427 ~ p.438
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Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway
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Zheng Xianjing
Liu Haimei
Ma Maoqiang
Ji Jianbo
Zhu Faliang
Sun Longru
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Abstract
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Over the past 100 years, Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) roots have been used to cure thromboangiitis obliterans (TAO) in local clinics. This study aimed to confirm the anti-thrombotic efficacy of 12 phenolic acids obtained from RSMA and to clarify the possible underlying mechanisms. The results of quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) experiments demonstrated that most of the phenolic acids markedly inhibited PAI-1 protein and mRNA levels but increased t-PA protein and mRNA levels in TNF-α-induced EA.hy926 cells (P?
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KEYWORD
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Salvia miltiorrhiza f. alba, Phenolic acid, Anti-thrombotic effect, TNF-α-induced EA.hy926 cells, NF-κB, JNK, p38 MAPK
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